Personalized 3D Printed Drugs – Can be Printed with Existing 3D Printers

SINGAPORE – A team of researchers from the National University of Singapore (NUS) has found a way to make cheaper and easily personalized medicine. This is done my combining many pills in one, take medicine once a day where it ends up being released slowly, tailored on patient’s needs.

The new method of making tablets has been designed by Associate Professor Soh Siow Ling and Sun Yajuan PhD student, Department of Chemical and Biomolecular Engineering, Faculty of Engineering. The new system can make customizable pills that release drugs with desired release profiles.

Certain chemicals, such as hormones, may have to be released in pulses at regular intervals in synchronism with the biological cycles of the human body. In other situations, higher doses at first and subsequently lower doses are required to maintain the effect.

While there are some existing production methods, such as 3D printing, which can allow for some flexibility, they have their limitations. These include low dose, continuous, or drugs which are released in a huge explosion at the beginning, and have little durability given the rapid decomposition of the tablet.  These methods also are only capable of making controlled release drugs with a limited type of profiles.

Custom

“For a long time, custom pills have been a mere concept because they were too complex or expensive to accomplish. This new manufacturing method is technically simple, relatively inexpensive and versatile. It can be applied individually, so that doctors produce customized event for patients, or in mass production, “says Soh, in the press release from the university.

Instead of manufacturing the printed layer by layer tablet, the tablet designed by Sun Soh and comprises three separate components including a polymer containing the drug, specifically designed to determine the release rate of the drug.  For example, a form of 5 points allows the drug to be released in five separate pulses.

Printer

The doctor only needs to draw the desired release profile in computer software to generate a template to make specific for the treatment of a patient, which can then be used to easily produce the desired pills using a 3D printer.

The system is easy to use and does not involve any complex mathematical calculations to create a new release profile.  It is completely customizable and is able to create any printable pills release profile template.

Since the method uses a commercially available 3D printer, also it makes it a relatively cheap way to carry out personalized medicine to reality, compared to other methods, such as photolithography.

In the administration of drugs, it is also often important to administer more than one type of drug simultaneously to treat a disease. The manufacturing method developed by Soh can be modified to include various types of charged drugs within the same tablet; and most importantly, each drug can be customized to free themselves at different rates, even within the same pill.

Stargoods 3D Printer Kit – Tempered Glass, Removal Tool & Painters Tape

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The newest 3D printer control board Rambo control board 3D printer

Rambo (RepRap Arduinoa compatible board) is an integrated motherboard, RAMPS class motherboard has the advantages of convenient use, reliable performance, for the 1.1A version. ATMEGA2560 Atmega32u2 processor compatible Arduino MEGA are compatible with all slope The road. USB and MCU products (Oppm to l accurate timing case) 4 thermal electric jack jump All the pins broke two (Sichuan 32u2 processor allows the AVR programmer, LUFA etc.) 2 channel SDRAMPS compatible SPI breakthrough Motor driver 5 A4982 1/16 Micro Motor Grab actuator (prior to A4984 1/8 to v1.1 (2) Z for joint Prusa. Mendel and other double Z printer design) Digital current control stepper series Trimpot VCC IC drive current limit, to prevent permanent lock The segmentation model through firmware (using any MCU configuration) The driving side pilot control signal The port pins synchronous movement of their ability to step and direction Port additional drivers trigger up to 3 additional Syria actuator (motor block and maximum expansion pin pin assignment extension share for SPI-SS) PWM DC output (extruder, fan etc.) 6 output Low power MOSFET cool running Each channel of the LED light Power With flexible power into the discovery of three independent power supply rail Warm bed, 15A (Il It limited version is less than 1.1 in turn 14A 16V 12-24V fuse positioning) Extruder and fan, 5A 12-24V (the fuse can be changed to the life of up to 10A capacity, 10V-26V) Input voltage 5A 12-24V (auto and logic, the fuse can be changed to up to 10A capacity, 1OV-26V). Input voltage The built-in 5V power generator into 2. PCB 4 layer All the copper layer on the 2oz High quality, high temperature FR4 TG130 PCB business Gold ENIG finishing The liquid crystal display panel support

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warped printed layer, new to printing

I am trying to print a PCB using the companies new Ultimaker 2+.  I have never used one before.  I did a few of the items that come on the SD card and decided to try to do some of the items that the company wanted prototyped.   the first PCB (printed circuit board) I did was a bit smaller but turned out ok.  on this board the edge warped.  Are their some guild lines or best practices that I missed with this item?  the fill was set at 15% and the shell thickness was 1.20 (mm)

here is an image of the warped board
20160527_073410

and here are a few screen shots of the set up.

print 1
print 2

any suggestions?

PLA, all “std” fan and heat settings  I was using Cura 15.04.5
I didn’t want to just right into a Beta software, but I have downloaded and installed 2.1.1

WER Aluminum Prusa I3 3D Printer DIY Kit Self-assembled 1.75mm Desktop Computer Reprap Printer

WER Aluminum Prusa I3 3D Printer DIY Kit Self-assembled 1.75mm Desktop Computer Reprap Printer

The printer is equipped with three plug wires, which are British standard, American standard, and European standard. Customers can choose one according to needs.

Printing specifications
Build volume: 200 x200x180mm
Layer resolution: 0.1-0.3mm
Positioning Precision: 0.1-0.3mm
Filament diameter: 1.75mm
Nozzle diameter: 0.3mm, 0.35 mm,0.4mm
Filament type: ABS/ PLA/Nylon Filament/Flexible PLA/Wood

Software
Operating system: Windows/Mac/Linux
Control software: Repetier-Host, Printrun
File format: .STL , G-code

Temperature
Max heated bed temperature: about 110°C
Max extruder temperature: about 240°C

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Power supply: Input: 110V/4.8A 220V/2.4A
Output:DC12V/15A
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Body: aluminum plate of 6 mm thickness (silver-grey)
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Shipping box: 520 x 420 x 230 mm
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Shipping weight: 11.5kg

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3D Printer Kit Clogged Extruder Nozzle (2each) .2mm .3mm .4mm .5mm bits + nozzles .2 .3 .4 .5mm + Tool MK7 MK8 Makerbot RepRap Felix more 3.0 3.1 Universal nozzle 1.75mm filament ABS PLA

3D Printer Kit Extruder Nozzle Head Cleaner Bits 1 each (2each) .2mm .3mm .4mm .5mm + 4 nozzles 0.2mm 0.3mm 0.4mm 0.5mm + Nozzle Cleaning Tool for MK7 MK8 Makerbot RepRap print nozzle for 1.75mm filament ABS/PLA printers

THE BITS: These Micro-drill bit Extruder Nozzle Cleaners are an essential item for any 3D printer owner. Every extruder nozzle must be cleaned out from time to time. These nozzles are very difficult to clean properly. These micro drill bits are of the highest quality, made in Japan. They are the perfect tool for the job. By using these precision drill bits, you will extend the life of your nozzle and without a doubt, produce finer prints. If you need another size or have any questions, contact us and we will take care of you.

THE NOZZLES: 1 each: 0.2mm 0.3mm 0.4mm 0.5mm
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THE TOOL
This multi-functional tool is perfect for hand cleaning the nozzle head to your 3D printer. You can use a drill to do the job, but the hand held tool is more safe. The high speeds of electric drills can cause damage to the nozzle head if the user does not have very steady hands. This tool is very easy to hold and compact at 3.5″ long.

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JET Top-level PLA Filament Tan Color 3.00mm 1.3kg/2.8lbs Food-grade Printing Materials for All 3d Printers

Weight: 1kg net weight, 1.3kg gross weight.

JET Filament Colors/Options: Nature, White, Green, Yellow, Purple, Orange, Red, Pink, Blue, Silver, Gold, Black, Brown, Grey, Transparent/clear, Lime, Navy, Olive, Violet, Magenta, Chocolate, Cyan, Burlywood, Royal, Blue,

SkyBlue, Khaki, Orchid, Maroon, Tan, Glow Green/Blue, Wood, PVA, Conductive ABS(acrylonitrile butadiene styrene),

PLA (polylactic acid) and HIPS (high impact polystyrene) filaments are the most commonly used printing supplies for all 3D Printers.

1) Filament not extruding properly?

A: Check the type of filament you’re working with and set the proper extruder temperature based on the filament type and heated build platform if applicable; If printing abs or hips, the platform should be heated more than 100°C Trial and error. Rule of thumb is to set the extruder temperature to the highest temperature for the specific filament, then decrease the temperature by 5°C until properly extruded. Please note this will vary with each 3D printer.

2) How do I store my filament?</p?
A: Most filaments tend to absorb moisture from the air; because of this your filament can become brittle and slowly degrade the quality. It's recommended to keep unused filament and store it in a storage container or zip lock bag with a desiccant.

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A: First, review FAQ #1. Second, for PLA it’s recommended to use blue painters tape and ABS it’s recommended to use kapton tape. If printing with ABS and the print will still not stick to the build platform you can use “*ABS Sludge” a little goes a long way. You can use this on the build platform on top of kapton tape.

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